1524
| Years: 1521 1522 1523 - 1524 - 1525 1526 1527 | |
| Decades: 1490s 1500s 1510s - 1520s - 1530s 1540s 1550s | |
| Centuries: 15th century - 16th century - 17th century | |
- April 30 - Battle of the Sesia - Spanish forces under Charles de Lannoy defeat the French army in Italy under William de Bonnivet. The French, now commanded by François de St. Pol, withdraw from Italy.
- August - September - Siege of Marseille by Imperial forces under the Duke of Bourbon
- October 28 - A French army invading Italy under King Francis besieges Pavia.
- Giovanni da Verrazzano is the first European to sight the island of Manhattan, the future New York City.
- The Peasants' War in Germany (1524-1525)
- Quiché capital of Gumarcaj falls to the Spanish Conquistadores
- May 28 - Selim II, Ottoman Emperor (+ 1574)
- December 24 - Vasco da Gama, Portuguese explorer
- Diego Velázquez de Cuéllar, Spanish conquistador