The Chymotrypsin reference article from the English Wikipedia on 24-Jul-2004 (provided by Fixed Reference: snapshots of Wikipedia from wikipedia.org)

Chymotrypsin

Chymotrypsin (bovine γ chymotrypsin: PDB 1AB9, EC 3.4.21.1) is a digestive enzyme that can perform proteolysis.

Activation of chymotrypsin

Chymotrypsin is synthesized by protein biosynthesis as a precursor called chymotrypsinogen that is enzymatically inactive. On cleavage by trypsin into two parts that are still connected via an S-S bond, cleaved chymotrypsinogen molecules can activate each other by removing two small peptides in a trans-proteolysis. The resulting molecule is chymotrypsin, three polypeptides interconnected via S-S bonds.

This is the "Chymotrypsin" reference article from the English Wikipedia. All text is available under the terms of the GNU Free Documentation License. See also our Disclaimer.