The Cyclic guanosine monophosphate reference article from the English Wikipedia on 24-Jul-2004
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Cyclic guanosine monophosphate

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Cyclic guanosine monophosphate (cGMP) is a [[second messengerEnlarge

Cyclic guanosine monophosphate (cGMP) is a [[second messenger

derived from GTP.]]

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP, most notably by activating intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.

Synthesis

cGMP synthesis is catalyzed by guanylate cyclase (GC) which converts GTP to cGMP. Membrane-bound GC is activated by peptide hormones such as the natriuretic factors, while nitric oxide typically stimulates cGMP synthesis in soluble GC.

Effects

cGMP is a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. It also relaxes smooth muscle tissues. In blood vessels, relaxation of vascular smooth muscles lead to vasodilation and increased blood flow.

Degradation

Cyclic nucleotide phosphodiesterases (PDE 1-6) degrade cGMP by hydrolyzing cGMP into 5'-GMP.

Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra®) enhances the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V). This is used as a treatment for erectile dysfunction. 



References