The HLA-B27 reference article from the English Wikipedia on 24-Jul-2004 (provided by Fixed Reference: snapshots of Wikipedia from wikipedia.org)

HLA-B27

Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the MHC on chromosome 6. It presents microbial antigens to T-cells and is strongly associated with certain immunity diseases (SpA spondyloarthropathies). In the general population, about 8% Caucasian, 4% African, 2-9% Chinese, and 0.1-0.5% Japanese have the HLA-B27 antigen. In Northern Scandinavia (Lapland), 24% of people are HLA-B27 positive while 1.8% have ankylosing spondylitis (AS).

HLA-B27 is also implicated in Reiter's syndrome, certain eye disorders, psoriatic arthritis and inflammatory bowel disease.

External link

• eMedicine - HLA-B27 Syndromes : Article by A Luisa Di Lorenzo, MBBCh

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