Sumatriptan

For people who check facts

Sumatriptan (Imitrex®) is a triptan drug originally developed by Glaxo for the treatment of migraine headaches. Several dosage forms for sumatriptan have been approved, including tablets, solution for injection, and nasal inhalers.

sumatriptan
4-methylaminosulfonyl-N,N-dimethyltryptamine
Chemical formula C H N O S . C H₆O₄
Molecular weight 413.5
Bioavailability 15%
Metabolism ?
Elimination half life 2.5 hours
Excretion 60% urine
40% feces
Pregnancy category C
Delivery 25mg and 50mg tablets
Indicated for:

migraine headache
cluster headache
Contraindications:

coronary artery disease
monoamine oxidase inhibitors
Side effects:

Severe:
coronary artery vasospasm
transient myocardial ischemia
myocardial infarction
ventricular tachycardia
ventricular fibrillation
hypertensive crisis
Atypical sensations:
paresthesia

Cardiovascular:
palpitations
syncope
hypertension
hypotension

Ear, nose, and throat:
tinnitus
sensitivity to noise
sinusitis
allergic rhinitis
upper respiratory inflammation

Gastrointestinal:
diarrhea

Muscular:
myalgia

Neurological:
phonophobia
photophobia

Respiratory:
dyspnea

Skin:
sweating

Miscellaneous:
hypersensitivity
Sumatriptan was the first triptan available (in 1993), and is available only by prescription in the United States.

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Triptans
{Almotriptan} {Eletriptan} {Frovatriptan} {Naratriptan} {Sumatriptan} {Rizatriptan} {Zolmitriptan}

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sumatriptan
4-methylaminosulfonyl-N,N-dimethyltryptamine
Chemical formula	C H N O S . C H₆O₄
Molecular weight	413.5
Bioavailability	15%
Metabolism	?
Elimination half life	2.5 hours
Excretion	60% urine 40% feces
Pregnancy category	C
Delivery	25mg and 50mg tablets
Indicated for: migraine headache cluster headache
Contraindications: coronary artery disease monoamine oxidase inhibitors
Side effects: *Severe:* coronary artery vasospasm transient myocardial ischemia myocardial infarction ventricular tachycardia ventricular fibrillation hypertensive crisis *Atypical sensations:* paresthesia *Cardiovascular:* palpitations syncope hypertension hypotension *Ear, nose, and throat:* tinnitus sensitivity to noise sinusitis allergic rhinitis upper respiratory inflammation *Gastrointestinal:* diarrhea *Muscular:* myalgia *Neurological:* phonophobia photophobia *Respiratory:* dyspnea *Skin:* sweating *Miscellaneous:* hypersensitivity